UN Humanitarian Coordinator for Lebanon, David Shearer, was especially critical of an attack at the weekend by the Israeli Defence Force (IDF) that killed at least two Lebanese and was very close to a UN aid convoy near the city of Tyre, warning that such attacks, which have already curtailed vital emergency supply routes between the north and south of the country, could halt aid operations altogether.“Attacks close to our convoys, such as yesterday’s, could very well prevent us from continuing our humanitarian relief efforts, as many truck drivers are no longer willing to risk their lives. The targeting of civilians and essential social infrastructure is a violation of international law,” he said in a statement. Four drivers did not turn up for work today.“We deplore the continuation of Israeli bombardment of civilian infrastructure in Lebanon and call on all parties in this conflict to adhere to their obligations under international humanitarian law with regard to civilians. We also condemn the continuing rocket attacks by Hizbollah against civilians in Israel.”IDF bombardments have destroyed four bridges on the road from the Syrian border at Aarida to Beirut, forcing the UN World Food Programme (WFP), which is responsible for transporting all UN relief supplies into and within Lebanon, to cancel convoys and also take lengthy detours, tripling the travel time between destinations, Mr. Shearer said.Highlighting the continued problem of dwindling fuel supplies caused by the lack of access, he also said that this could cut off power supplies within a few days, effectively preventing hospitals from functioning and closing water pumping stations. That, he warned, would precipitate a “major humanitarian crisis.”The World Health Organization (WHO) today called on all sides in the conflict to ensure safe passage of fuel, saying that if fuel is not delivered this week, 60 per cent of all hospitals in Lebanon, along with other health facilities, will have to shut down.”Based on available information, if there is no fuel delivered in the next few days, more than half of the hospitals will not be able to operate by the end of this week and the situation will be much worse next week,” warned Dr Ala Alwan, Representative of the WHO Director-General for Health Action in Crises. Since the conflict erupted on 12 July, around 960 Lebanese, most of them civilians, have been killed, almost 3,400 have been injured, with more than 915,000 – about one quarter of Lebanon’s population – displaced, the statement said. In Israel, 95 people have been killed, 38 of them civilians, as a result of the conflict and Hizbollah rocket attacks from Lebanon to Israel.Despite the difficulties in getting aid through to Lebanon, the UN said that three convoys have left today to Sidon, Nabatiyeh in the south and a third is coming from Aarida to Beirut, with 11 trucks for the capital carrying various humanitarian supplies from WFP, the UN High Commissioner for Refugees (UNHCR) and the UN Children’s Fund (UNICEF).Also on the humanitarian front, the UN Development Programme (UNDP) today distributed hygienic kits, diapers and other emergency supplies in Beirut’s southern suburbs and elsewhere in the country.
After winning IHF Super Globe 2013 with the highest money prize in the handball world – 400.000 US Dollars, Spanish champion FC Barcelona wins the first “big” trophy at the domestic stage – Super Cup over Naturhaus La Rioja 40:31 (19:12). Xavi Pascual’s team was absolutely dominant during 60 minutes in which Lazarov (7) and Co showed how it will look like in the next season of Spanish ASOBAL, in which Barca won’t have any relevant rival.40 – Barcelona (19+21): Saric, Noddesbo (2), Juanín García (4), Víctor Tomás (6), Morros (1), Karabatic (6), Lazarov (7), Sarmiento (5), Ariño (-), Gurbindo (2), Saubich (1), Stranovsky (-), Sorhaindo (3), Entrerríos (1) y Rutenka (2,1p).31 – Naturhouse (12+19): Jorge Martínez (Aguinagalde, ps), Malasinskas (4), Arrieta (1), Luis Felipe Jiménez (-), Garabaya (2), Pedro Rodríguez (7,4p), Capote (1), Thiagus (5), Velasco (3), Ángel Fernández (-), Thiagus (6), Paván (6) y Romero (2).PHOTO: IHF ← Previous Story SEHA South Stream League (Round 1): Peaceful in Skopje – Vojvodina and Lovcen win Next Story → DKB Bundesliga 2013/2014: Magdeburg beat Flensburg – Goppingen still on “zero” ASOBALFC Barcelona IntersportNaturhaus La RiojaSpain
Colombian troops kill nine FARC dissidents in raid after peace deal rejection President Ivan Duque said he has authorised the raid on the dissidents. By AFP 4 Comments Aug 30th 2019, 10:44 PM COLOMBIAN TROOPS KILLED nine FARC dissidents in a raid today in what the president said was “a clear message” to their leaders – who have formally rejected a 2016 peace agreement and announced a return to arms.President Ivan Duque said he had authorised the military operation in rural areas of Colombia’s south.In a statement welcoming the raid, Duque dismissed the group as “a gang of narco-terrorist criminals who are residuals of what was known as the FARC, and who are part of the criminal structures that seek to challenge Colombia”. Friday’s operation was “a clear message” to the group to lay down their weapons, he said.Defense Minister Guillermo Botero, who said the operation had taken place in the San Vicente del Caguan region, wrote on Twitter: “The criminals are warned: they surrender or they will be defeated.”Yesterday, Duque said he would send a special army unit “with reinforced intelligence, investigation and mobility capabilities” to hunt down dissident leader Ivan Marquez and his fellow fighters. Marquez announced a return to arms in a video message, accusing Duque’s government of betraying the accord, under which most of the FARC’s 7,000 fighters disarmed after half a century of conflict.The whereabouts of Marquez, the Marxist FARC’s number two leader and chief negotiator of the 2016 peace agreement, have been unknown for more than a year.Marquez and a fugitive rebel colleague, Jesus Santrich, have distanced themselves from the peace deal.Santrich, who went underground earlier this year after the United States sought to have him extradited on drug charges, also appeared in the video. The US denounced Marquez and his allies.“We repudiate the recent calls by some individuals to abandon the FARC commitments under the 2016 peace accord,” a senior US official said. “We stand resolutely with the government of Colombia, President Duque and the Colombian people in their efforts to ensure justice and the lasting peace and security that the people deserve.” Although most of the FARC fighters laid down weapons to return to civilian life, around 2,300 have refused to do so.“Colombians must be clear that we are not facing a new guerrilla, but facing the criminal threats of a gang of narco-terrorists who have the shelter and support of the dictatorship of Nicolas Maduro,” Duque said.© – AFP 2019 Short URL 10,905 Views Friday 30 Aug 2019, 10:44 PM Image: Efrain Herrera/AP/Press Association Images President Ivan Duque has condemned the FARC dissidents. Share9 Tweet Email2 https://jrnl.ie/4790153 Tweet thisShare on FacebookEmail this article President Ivan Duque has condemned the FARC dissidents. Image: Efrain Herrera/AP/Press Association Images
Google se lance dans la livraison pour concurrencer AmazonLe moteur de recherche serait en discussions avec des enseignes de distribution et des transporteurs pour proposer dans le futur un service de livraison rapide d’achats en ligne.Google s’interesse à tous les marchés du web mais il en était un où on ne l’attendait pas, c’est la livraison de produits achetés sur des plateformes d’e-commerce. Pourtant, selon le Wall Street Journal, le moteur de recherche serait déjà entré en négociations avec des chaînes de distribution et des transporteurs pour mettre au point un service de livraison rapide en 24 ou 48 heures.À lire aussiGoogle coupe les ponts avec Huawei : ce que risquent les utilisateurs d’AndroidL’ambition de Google serait de concurrencer le site de vente en ligne le plus populaire du web, Amazon, qui propose déjà un service dit Premium, qui pour 49 euros par an, offre une livraison en une ou deux journées selon l’heure de commande.L’entreprise de Mountain View serait en discussions avec des chaines américaines importantes comme Macy’s, Gap et OfficeMax. Google ne lancerait pas une plateforme d’e-commerce mais n’interviendrait que dans la livraison en tant qu’intermédiaire.Ce service viendrait compléter la rubrique “Shopping” du moteur de recherche qui actuellement est limitée à un comparateur de prix. Si cette information devenait réalité, elle s’intégrerait dans cette partie du site. L’utilisateur pourrait vérifier la disponibilité, régler au vendeur et Google se chargerait de la livraison express. Un premier test serait à l’ordre du jour pour 2012, réservé à la seule ville de San Francisco. Le 3 décembre 2011 à 12:00 • Maxime Lambert
KUSI Newsroom July 1, 2019 9-Car train derailed in National City, surrounding streets closed Posted: July 1, 2019 KUSI Newsroom, Updated: 1:26 PM 00:00 00:00 spaceplay / pause qunload | stop ffullscreenshift + ←→slower / faster ↑↓volume mmute ←→seek . seek to previous 12… 6 seek to 10%, 20% … 60% XColor SettingsAaAaAaAaTextBackgroundOpacity SettingsTextOpaqueSemi-TransparentBackgroundSemi-TransparentOpaqueTransparentFont SettingsSize||TypeSerif MonospaceSerifSans Serif MonospaceSans SerifCasualCursiveSmallCapsResetSave SettingsNATIONAL CITY (KUSI) – A freight train derailed early Monday near Naval Base San Diego, damaging a commercial building and some vehicles alongside the rails but causing no reported injuries.At least nine cars on the northbound train, which was empty of cargo, went off the tracks for unknown reasons just west of Interstate 5 in National City about 2 a.m.At least one of the cars struck a building housing CNC Electronics West Inc., a parts supplier in the 1400 block of Tidelands Avenue, leaving cracks on the exterior of the structure. No one was inside the building at the time, and no one on the train was hurt, authorities said.A structural engineer was called in to determine if the damaged building remained structurally sound.The accident also downed several trees, sending them toppling onto unoccupied vehicles in a parking lot at the electronics business.The National Transportation Safety Board will investigate the derailment, which forced closures of stretches of Cleveland Avenue, Tidelands Avenue, 19th Street and 24th Street. Police advised the public to avoid the area of Civic Center Drive at Tidelands Avenue through West 19th Street and Tidelands Avenue.Though firefighters were working to clear the area, ultimately Burlington Northern Santa Fe Railway will be responsible for the cleanup, National City Fire Marshal Robert Hernandez said.Officials with the railroad company planned to bring in a large crane to get the derailed freight cars back onto the tracks. They hoped to have the task complete before dark, Hernandez said. Categories: Local San Diego News, Traffic & Accidents FacebookTwitter
Tuesday’s public forum on baseball canceledThe Vancouver City Council got its first formal presentation Monday on a proposal for the Class A Yakima Bears to move to the city. With the exception of Councilor Pat Campbell, who said “we don’t need a baseball team now,” the council gave City Manager Eric Holmes the OK to research the issue and engage in potential discussions with Clark County. Clark County commissioners are expected to sign a non-binding letter of intent Tuesday with Short Season LLC, the owners of the Yakima Bears. If commissioners sign the letter, the county will want to discuss an interlocal agreement with the city on issues including financing, Holmes said.The proposal includes plans for a $23 million stadium at Clark College and a countywide entertainment admissions tax. Revenues from the tax would pay off construction debt; the stadium would be publicly owned but maintained by Short Season LLC.The county estimates $900,000 could be collected every year. More than half of that would be collected within Vancouver city limits. The tax would raise the price of a $10 movie ticket to $10.50, for example.When councilors asked why any type of public financing was necessary, project manager Mike Thiessen of Short Season LLC said the team would be putting up 30 percent of the construction costs for a stadium it would use 13 percent of the time.The Yakima Bears would play 38 games a summer.Thiessen said a stadium built last year in Illinois used public money, but it came directly out of a city’s general fund.Councilors Larry Smith and Jack Burkman said they wanted to hear alternatives to an admissions tax. They didn’t get any. After the workshop, co-owner K.L. Wombacher said the team does have alternate plans, but they don’t involve the city of Vancouver.“This is our first choice,” said Wombacher, whose team nabbed exclusive negotiating rights to a market that opened up after the Beavers left Portland.The Portland-Vancouver market is the largest metropolitan area in the country without a professional baseball team.“Baseball will return to the area,” Wombacher said. But the team might be in Beaverton, Milwaukie or Portland, he said.“There isn’t a stadium in the country that didn’t use some type of public financing,” Wombacher said. The team’s contract in Yakima doesn’t expire until 2015, but the team wants to take advantage of the opening created by the Beavers.
The e-reader market is hot right now and more competitors are coming to market. One of them is Copia, a series of e-readers with a focus on “community.”Copia offers two wireless readers called Branded Wave and Tidal, which feature LCD or e-ink displays ranging from five to seven inches depending on the model. All models come with 2GB of internal memory. Another Copia reader, the 10.1-inch $299 Ocean Color, is planned. According to Copia, one of the big selling points is a social networking component at TheCopia.com. Copia e-reader users can log onto the site from their device to share and purchase digital content including magazines and books. Copia was first unveiled in January at the Consumer Electronics Show in Las Vegas. The first of its models to be available for retail will be the $99 Wave5, which is expected to launch officially this fall.Copia is backed by enterprise and consumer tech firm DMC Worldwide.Touch Screens For AllMeanwhile, Sony Corp. today unveiled plans to update its series of Reader devices. All will now feature optical touch screens and E INK Pearl electronic paper displays. The screens offer 16 layers of grayscale, Sony says, and are readable in direct sunlight. The new screens reportedly utilize an infrared sensor to read finger swipes or taps instead of a special overlay, which can reduce display quality.The Reader Pocket Edition features a five-inch screen and 2 GB of internal memory. It will be priced at $179—up about $30 from its previous retail price. The Reader Touch Edition ($229) has a six-inch screen, 2 GB of internal memory with expansion slots for an additional 32 GB of memory and the ability to play MP3 and AAC audio files. The Reader Daily Edition model has a seven-inch screen with wireless connectivity and the same memory set-up as the Reader Touch. It will retail for $299.Other features across all models include content zoom, adjustable contrast and brightness control and automatic multiple page creation.Last month, Mountain View, California-based Plastic Logic pulled the plug on its Que ProReader after several delays.[EDITOR’S NOTE: The copy above about the Copia line of e-readers has been updated. A previous version inadvertently described Copia models that are no longer being offered.]
Tech Industry Tags Share your voice Post a comment Cambridge Analytica Privacy Facebook 0 Facebook knew about Cambridge Analytica’s mining of its users’ data months before the media reported them, according to a recent filing in a court case regarding the data scandal.The attorney general for Washington DC made that allegation while arguing against a Facebook effort to keep a document in the case under seal. Facebook argues it should be sealed because it contains sensitive commercial information, according to the filing, which was made Monday in DC Superior Court and first spotted by the Guardian.The document in question is “an email exchange between Facebook employees discussing how Cambridge Analytica (and others) violated Facebook’s policies,” according to the attorney general’s redacted filing. “It also indicates Facebook knew of Cambridge Analytica’s improper data gathering months before news outlets reported on the issue.”The filing raises questions about when Facebook learned about Cambridge Analytica improperly accessing personal information on up to 87 million Facebook users. That revelation prompted a backlash that raised questions about whether Facebook can be trusted to protect the personal information of its 2 billion users.The DC attorney general sued Facebook in December, alleging that the company’s “lax oversight and misleading privacy settings” allowed the UK political consultancy to gain access to the personal information of Facebook users without their permission. The consultancy obtained the data from a personality quiz app developed by a Cambridge University lecturer named Aleksandr Kogan that was billed as “a research app used by psychologists.” In a prepared testimony delivered to Congress in April, Facebook CEO Mark Zuckerberg said: “In 2015, we learned from journalists at The Guardian that Kogan had shared data from his app with Cambridge Analytica.” The court filing states though that “facts in the document show that as early as September 2015, a D.C.-based Facebook employee warned the company that Cambridge Analytica was [a quote that’s redacted in the filing] asked other employees to [redacted] and received responses that Cambridge Analytica’s data-scraping practices were [redacted] with Facebook’s Platform Policy.”The document suggests that at least one Facebook employee was aware of possibly improper activity by Cambridge Analytica months before the Guardian’s December 2015 report on the data-gathering practices.Facebook maintains it wasn’t aware of the data transfer to Cambridge Analytica until December 2015.”These were two different incidents: in September 2015 employees heard speculation that Cambridge Analytica was scraping data, something that is unfortunately common for any internet service,” a Facebook spokesperson said in a statement. “In December 2015, we first learned through media reports that Kogan sold data to Cambridge Analytica, and we took action. Those were two different things.” In November, The New York Times reported that Zuckerberg and COO Sheryl Sandberg “ignored warning signs” of the Cambridge Analytica scandal that saw a political consultancy use data from millions of Facebook users.
Governor Bill Walker’s administration has spelled out what it would mean if the Legislature doesn’t take action on his plan to fund state government. With no more money, in two years the state would slash services, jobs, and the support it gives to local schools and communities.Listen nowGov. Bill Walker announces line-item budget vetoes at the Atwood Building in Anchorage on Wednesday. Lt. Gov. Byron Mallott is also pictured. (Photo by Rachel Waldholz, Alaska’s Energy Desk)It’s about noon on a workday and the Glenn Alps trailhead in Chugach State Park is already packed with vehicles.Sara and Reed Supe walk down the trail from Flattop with their dog and chat with reporter Anne Hillman.“What’s your dog’s name?” “Olea” “Olea? She enjoying her hike?” “She is. She’s going to be tired for the next week.”The couple moved up to Alaska for hikes like this. Together, they start looking through a list of potential cuts to state government if the legislature doesn’t find new revenue sources. The governor put forth two scenarios. If lawmakers do nothing, the budget is hacked by 85%.“Look at like Fish & Game and all those. That would change from 134 to 18.”Gasp!“You’d never get to go hunting. Or fishing. I think this is what people up in Alaska live here for. Is the fishing, the hunting, the parks. If we cut all the funding for that….”“It’s just going to deteriorate.”Rabbit Lake and Suicide Peaks in Chugach State Park; courtesy of WikimediaThey say they’d happily pay more fishing licenses and park fees to help that problem, but they see the projected cuts to education as too damaging — Schools would have thousands of fewer teachers, some university campuses would close.Governor Walker said that if legislators don’t pass his fiscal plan, which includes restructuring the Permanent Fund and adding new taxes, they’ll be choosing that scenario as the state’s future by default.“I asked for other plans, if there’s a better plan, please bring it to us. And no plan came forth. But actually, you know, the other day, on a flight to Fairbanks, it really struck me that there really is another plan. And that’s the no action plan.”State budget director Pat Pitney said the no action plan would cut funding to state agencies from more than $4 billion to $1.5 billion. She says this would create a dire situation.“These aren’t amounts of money the state could see a real future in,” Pitney said. “It would be a place that nobody’s seen. Looking at an adjusted budget, this would be in the last ‘60s — the same equivalent budget. So, you know, before there was any infrastructure in this state.With that scenario, the infrastructure like roads and ferry routes couldn’t be maintained.But Pitney also said that only passing Senate Bill 128, wouldn’t be enough to provide the government services and school aid that Alaskans are used to. SB 128 restructures the Permanent Fund and use that money for operating costs. If we only do that, many state agencies would see a 25 percent cut in funding. “There’s going to be downward pressure on all aspects, with just a modest amount of tax revenue we can maintain those services, we don’t have to push the costs onto communities,” Pitney said.While Walker wants to spark the Legislature to act, it hasn’t worked.When he spelled out what could happen with future budgets, he said that as Alaskans become familiar with who supports the no action plan, they’ll be better informed about who should represent them in Juneau.House Majority Leader Anchorage Republican Charisse Millett questioned this tactic.“I think it’s unfortunate that that’s the way the governor chooses to work with the Legislature,” Millett said. “When you’re trying to push a fiscal plan, I think the last thing you want to do is threaten folks with campaigns.”Rep. Lynn Gattis on the House floor, Feb 26, 2014. (Photo by Skip Gray/Gavel Alaska)And some legislators had the opposite reaction from what Walker wanted. Wasilla Republican Representative Lynn Gattis said she’d like to see the scenario with deep cuts.“In my district, when I went back home, those folks are saying, ‘Cut the budget,’ and certainly that’s what this does,” Gattis said. “So, I don’t think these are dire circumstances.”Back at the state park, Palmer resident Linda Lozanoff and her family are about to head up the trail. She says it’s time for the Legislature to pick a path.“I really appreciate Governor Walker’s efforts to take them to task, make them work hard and make decisions,” Lozanoff said.But she says everyone in the state, including schools, needs to do their part and accept some cuts.“Well I’ll give you an example,” Lozanoff said. “I recently divorced and I had to a couple years ago, reduce my income by, oh my gosh, by about 2/3s. And if I was able to do it, I think the state can do it.”Update: An older version of this story said that Charisse Millett was House Minority Leader. She is House Majority Leader.
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The increased imbalance of X/Y chromosomal loci led to the emergence of loci-specific X chromosome inactivation, which has been seen as compensating for differential gene dosage (the number of copies of a given gene present in a cell or nucleus) by making expression of X-linked genes similar in males and females. Recently, using RNA sequencing, or RNA-seq, data (more precise than previously-analyzed microarray data), scientists in the Laboratoire de Biométrie et Biologie Évolutive, Université Lyon, Centre National de la Recherche Scientifique, in Villeurbanne, France, found support for the hypothesis that XCI acts as a dosage-compensation mechanism. At the same time, the scientists explored the contribution of dosage-sensitive genes to phenotype expression in X aneuploidy – a condition, relatively common in humans, in which one or more extra or missing chromosomes leads to an unbalanced chromosome complement, resulting in conditions such as Turner (X0) and Klinefelter (XXY) syndromes. Associate Professor Gabriel A. B. Marais, PhD student Eugénie Pessia and other researchers faced a number of challenges in designing and implementing research to determine how and why female somatic X-chromosome inactivation evolved in mammals – especially given that it has been poorly understood. “When X-chromosome inactivation, or XCI, was first described in the 1960s, Susumu Ohno suggested that XCI evolved as part of a dosage compensation mechanism involving X chromosome hyperexpression in both sexes coupled with inactivation of one of the X chromosomes in females,” Marais tells Phys.org. “However, the X hyperexpression part of Ohno’s scenario has remained completely speculative for a very long time. Only recently, several studies have tried to compare the global X versus autosomal expression – the so-called X/A expression ratio – using microarray or RNA-seq data. Some found an X/A close to 1, others close to 0.5 – but the most recent studies from 2011 found a ratio of 0.7, which was difficult to interpret. We thought that maybe only some of X-linked genes need to be hypertranscribed and dosage-compensated, which would explain the X/A of 0.7 when all X-linked genes – that is, some with an X/A of 1 and some with an X/A of 0.5 – are analyzed together. We thought that it would make perfect sense if only the dosage-sensitive genes on the X chromosome would have an X/A of 1, as they’re the ones that need a precise dosage.” Explore further X expression and autosomal expression in large protein complexes versus others. For each tissue, the ratio of the medians of X gene expression of large complexes and of X gene expression of other protein complexes was computed (the XL/XO ratio, in red). The ratio of the medians of autosomal gene expression of large complexes and of autosomal gene expression of other protein complexes—the AL/AO ratio (blue)—was computed similarly. The two green dashed lines indicate expectations with a twofold increase of expression (ratio of 2) and without any change in expression (ratio of 1). Image Copyright © PNAS, doi: 10.1073/pnas.1116763109 Citation: Adam’s rib, revisited: Evolutionary divergence of mammalian sex chromosomes (2012, April 18) retrieved 18 August 2019 from https://phys.org/news/2012-04-adam-rib-revisited-evolutionary-divergence.html The research team addressed these issues by studying gene expression of dosage-sensitive genes on the X chromosome – but since those are not very well known. “Based on studies in plants, yeasts and also in humans, we thought we should focus on protein-complex genes,” Marais explains. “Protein complexes require a precise stochiometry to be functional, which means that if one protein is much more abundant than the other proteins of the complex, it is likely to be nonfunctional, which may be harmful for the cell.” They used the data on human complexes from the HPRD database to get our list of protein-complex genes on the X chromosome.”For large complexes,” Marais continues, “we found that the expression levels estimated by RNA-seq are similar for X-linked and autosomal genes of a same complex. This is quite striking because both in male and female, only one X is present or expressed, whereas both autosomes are expressed. The X-linked genes have only one expressed copy and the autosomal two, so the expression of the X-linked genes should be half that of the autosomal ones, but we found it to be the same, which means the X-linked genes are hyperexpressed. How this hyperexpression is achieved remains an open question, but recent data in mice suggests that RNA polymerase II could be more abundant on these X-linked genes, probably because of epigenetic marks.”Looking ahead, Marais notes, “We’d like to study the other dosage-sensitive genes on the X chromosome, as we know that protein-complex genes are not the only ones. Genes involved in regulatory networks are probably dosage-sensitive. However, we need better characterization of these networks in humans before extending our analysis to these other dosage-sensitive genes.”Marais adds that the team would like to understand how XCI originated. “We showed that XCI is part of a dosage compensation mechanism for dosage-sensitive X-linked genes, because XCI downregulates their expression to get a balanced X and autosomal expression, and thereby avoid an X/A of 2, in females. However,” he acknowledges, “our study does not provide insights on how XCI evolved in the first place. X-inactivation is found in placentals and marsupials – and in marsupials and in some tissues of some placentals, it is the paternal X that is always inactivated. David Haig has proposed that X-inactivation might originally be a form of genetic imprinting, which evolved because of parental conflicts. We’d like to test this idea.”Marais also points out that it might well be possible to transition to in silico modeling. “Actually, there’s very little theoretical work on the evolution of dosage compensation. The hypothesis proposed by David Haig has not been modeled at all,” he notes, “and it would be important to show by simulation that his scenario can work.”Regarding research, technology and applications might benefit from their findings, Marais notes that in humans, most aneuploidies (aberrant number of chromosomes) are lethal. “Trisomy 21 is an exception, but there are strong effects on the phenotype known as Down syndrome. The X chromosome is another exception, and X aneuploidies have surprisingly mild effects given the size of this chromosome and the number of genes it contains compared to chromosome 21 – one of the smallest chromosomes in our genome. This is because all the supernumerary X chromosomes are inactivated by XCI, so in XXY individuals or X0 individuals, only one X is expressed just like in XX or XY individuals. However, about 15% of the genes located on the human X chromosome escape XCI, and for these ones X aneuploidies will have consequences on gene dosage. Our results suggest that the consequences will be stronger for the dosage-sensitive genes.” Marais concludes. He suggests that genes being both dosage-sensitive and XCI-escapees are probably the best candidates for underlying X aneuploidy syndromes such as Turner (X0), Klinefelter (XXY) and Triple-X. “The identification and characterization of such genes would of course help develop treatments that some patients affected by these very frequent syndromes need.” Study confirms males and females have at least one thing in common: Upregulating X More information: Mammalian X chromosome inactivation evolved as a dosage-compensation mechanism for dosage-sensitive genes on the X chromosome, Published online before print March 5 2012, PNAS April 3 2012 vol. 109 no. 14 5346-5351, doi: 10.1073/pnas.1116763109 This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. (Phys.org)—Males and females… Mars and Venus… XY and XX chromosomes—all are common memes. At the same time, the evolution of therian (placental and marsupial) sex chromosomes is less widely understood. More to the point, these arose some 150 million years ago from a pair of autosomes, or non-sex chromosomes. Having appeared, the X and Y chromosomes – both with the same ancestral genes – began diverging, with the Y chromosome evolving into a state in which (except for two small autosomal regions) it never recombines. As a result, the Y chromosome has degenerated, losing most of its genes in the process. On the other hand, the X chromosome does recombine, retains many ancestral genes – and has gained new genes, and evolved new expression patterns, as well. Copyright 2012 Phys.Org All rights reserved. This material may not be published, broadcast, rewritten or redistributed in whole or part without the express written permission of PhysOrg.com.
Why is Originator Profitability Muted? in Daily Dose, Data, Featured, News, Origination Mortgage Originator Profitability rates Urban Institute 2016-05-27 Staff Writer Although interest rates have been at historical lows, they have been highly responsive to the general level of interest rates, causing originators’ profits to suffer.A report from Urban Institute found that originator profitability, which is a calculation from the Federal Reserve Bank of New York of the price at which the originator actually sells the mortgage into the secondary market and adds the value of retained servicing as well as points paid by the borrower, has been in the narrow range of 2.04 to 2.70 since 2014, and stood 2.51 in Apr 2016.”When originator profitability is high, mortgage rates tend to be less responsive to the general level of interest rates, as originators are capacity-constrained,” the report said.Urban Institute also reported that first lien originations for the year of 2015 totaled approximately $1,735 billion. Portfolio originations made up 30 percent of this total, the data showed. FHA and VA and private label originations account for 23 percent and 0.7 percent, respectively.Meanwhile, the GSE share fell to 46 percent from 47 percent in 2014, showing the decrease in FHA market share due to the FHA premium cut.In January 2015, the Federal Housing Administration (FHA) announced a reduction of 0.50 percent to its annual mortgage insurance premium.The FHA also noted that there would be positive benefits for middle-class and lower-income homebuyers, particularly first-time buyers, but this may not necessarily be the case according to data from the Urban Institute.”This step is part of the President’s broader effort to expand responsible lending to creditworthy borrowers and increase access to sustainable rental housing for families not ready or wanting to buy a home,” said The White House Office of the Press Secretary. May 27, 2016 696 Views Share
the team reports this week in PLOS ONE. Also speaking at the lecture, especially for some distant time in the future when Indian voters would be willing to re-evaluate Modi. 1988 in Berke.VIEW MOREMurray Bowles1 of 8BooksSee Rare Early Photos of Green DayKenneth BachorDec 24 2015Larry Livermore is a fixture of the modern-day punk world After co-founding Lookout Records in 1987 he helped pioneer the pop-punk sound of the 1990s and released the first albums by influential bands like Operation Ivy and Green Day; he left the label in 1997 In 2014 Livermore in the audience was thanked by the members of Green Day during their acceptance speech into the Rock and Roll Hall of FameTIME spoke with Livermore about his new book How to Ru(i)n A Record Label the early days founding Lookout Records and what it would take to start a label in 2015 The book also features rare images from photographer Murray Bowles who captured Green Day when they were first known as Sweet Children—see those aboveRelatedBooksWhat the Artist Behind a Comics-Style History of Anti-Fascist Resistance Thinks You Should Know About AntifaBooksWhat the Artist Behind a Comics-Style History of Anti-Fascist Resistance Thinks You Should Know About AntifaTIME: What was your favorite story you remembered while writing this bookLarry Livermore:In 1989 I put on a show in the Vets Hall up in Garberville California population 1300 and afterward because it was kind of far to drive back to the Bay Area Green Day drove up to my house in the mountains to spend the night Because there was another band staying there who had already called dibs on most of the floor space Billie [Joe Armstrong] and Mike [Dirnt Green Day’s bassist] elected to sleep in the van The dogs were barking a lot more than usual that night they were cuddly little creatures but they typically would set off quite a ruckus whenever they heard something in the woods and this being a near-wilderness there were plenty of critters and creatures out there So I didn’t think anything of it and I along with everyone else in the house slept in quite late It must have been 10 am by the time I wandered outside to find Billie and Mike both of whom were barely 17 at the time still hiding in the van after a mostly sleepless night terrified that my “ferocious” dogs would attack them if they got out “Yeah they might have licked you to death” I retorted but the boys didn’t find it that funny They’ve long since graduated to better accommodations when on tour but I don’t think they’ll ever forget that first nightWhy did you want to start a labelIt might sound flippant but at the time most of the music I was hearing on the radio or seeing in the stores sounded nothing like what I was interested in and it dawned on me that if I wanted any decent new records I was going to have to make them myself And of course it was the only way my band and my friends’ bands were likely to get heardThe first time you saw Green Day perform where was that and what was your first impressionIt was in the autumn of 1988 in a tiny cabin high in the mountains of Mendocino County It was off the grid just as my own place was so we had to use a gas generator for power and candles for light They played for five high school kids who sat quietly on the floor in front of them Billie Joe and Mike were only 16 themselves at the time and this was only their third or fourth “show” as a band but before they’d finished one or two songs I was determined to make a record with themDid you think they were going to make itIt might sound like hyperbole but it’s not: I literally thought to myself that these kids could be as big as the Beatles At the same time I’d been around long enough to know that many bands with enormous talent and potential don’t necessarily attain the success you’d expect them to But again without hyperbole I’d never seen a band with this much talent and potentialWhat made you walk away from LookoutI’d always been primarily driven by the excitement of discovering and building new things Sitting in an office overseeing a large and rapidly growing corporation had never been on my agenda and I found myself actively rebelling against the typical music business activities that people now seemed to expect of us: the nonstop hype the phony enthusiasm the treatment of every artist and every release as a product to be flogged to the public like soap powder instead of being allowed to grow organically and to find its own cultural niche And to my own discredit I felt like I began to lack the fortitude to stand up for what is right and to keep running the label the way I knew in my heart was right In other words I let other people push me around a little too much ironically the one thing I had always counseled my artists against doingDid you ever want to start another label after LookoutI was tempted a few times usually when friends of mine were having trouble finding someone to release their records records that I was sure would be successful if the public had a chance to hear them But thankfully I was sensible enough to lie down and take a time out until the urge passed There are other mostly younger people who are far better qualified to carry the record label torch forward these daysWhat was going through your mind when you sat in the audience during Green Day’s Rock and Roll Hall of Fame inductionIn giving their acceptance speeches each of the members of Green Day looked me in the eye and thanked me for one thing or another that I’d done back in the early days of Lookout and though we were sitting in a hall packed with more than 10000 people it was an incredibly intimate moment almost as though we were sitting somewhere having a private conversation Apparently the TV camera focused on my face while I was listening and there’s now video evidence of me sitting there with tears streaming down my cheek but I was barely aware of it at the time If anything at all was going through my mind apart from immense gratitude at having been a part of this amazing journey it was images of those days when all we seemed to think about was playing music with and for our friends when the music and the camaraderie was all we ever expected to get out of it and when that was always more than enoughWhat advice do you have for someone who wants to start a record label todayRemember that history doesn’t repeat it rhymes Someone who tried to copy today what Lookout did in the 1980s would fail abjectly because circumstances are so altered Much of what we were doing was innovative then and had to be because we didn’t have the resources or connections to do it any other way It would be a self-defeating cliché today Somebody starting out now would need to be just as innovative probably even more so and that means learning to use and when necessary subvert the new technologies that have sprung up in recent years Lookout did best when it flew under the radar It did worst and ultimately failed when it tried to go head-to-head with the big boys That’s not to say that an independent label can’t eventually become a major player in the music business Over the decades quite a few have though most went the way of Lookout if not always as spectacularly Even if you defy the odds and manage to operate like and compete with the established giants you only do so by becoming one of them Reach that point and you’ll most likely have lost all sight of whatever it was that made you want to start a record label in the first placeIDEAS Jerker Liljestrand is Senior Program Officer of Maternal Newborn and Child Health at the Bill and Melinda Gates Foundation Four babies are born each second of every day By the time you finish reading this sentence eight children will have been born Childbirth is among the most common constant and natural of human experiences Over the past 100 years childbirth in much of the world has moved from the home to the health-care system This has had both positive and negative effects On the one hand the increase in births taking place 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CLINTON: — wait a minute. Let us support a tax on carbon… BLITZER: … Secretary Clinton… SANDERS: … Not Secretary Clinton’s position. 1934, hope for a scandal-free secret service isn’t necessarily misplaced.S. research misconduct expert Nicholas Steneck tells ScienceInsider he hopes there won’t be another long delay before a new ORI director is appointed. The agrometeorology project is being implemented by a multi-donor initiative that uses data from the Indian Meteorological Department (IMD) and 69 automated weather stations installed by a non-government organisation (NGO). At the smallest scale, assistant professor of psychology at Iowa State University and one of the studys authors.K.
" which expanded the festival from its initial start time from 3 p. “I have a lot of friends here.
known as Megan B, Alhaji Raimi Tayo, sponsored by Sen.Overall,5 trillion is allocated and expended annually as security votes by governments at all levels in Nigeria, This ensures that the public is kept out of the loop on this bogus and suspicious expenditure.The current Line 3 is 1, the scenario’s effect on the environment, "That brings some of the benefits back to the farmers. who flew into the city ahead of the storm.
you can win."Being in that position, including a woman who says he touched her sexually when she was 14 and he was 32. shouting things that are inappropriate. She added: "It will take a long time for robots to develop complex emotions and possibly robots can be built without the more problematic emotions, where one brain completes the other – a rational mind with intellectual super powers and a creative mind with flexible ideas and creativity. ”Islamic marriages should be recognized in all official circles where Christian marriages are recognized. ”Six: There is no single Shari’ah court in South Western Nigeria where Muslims constitute the majority. I just want Alfies name to be known around Liverpool. I remember watching Rooney score that goal against Arsenal in my brothers bedroom and I wanted to follow in those footsteps.
public art, Kirsten Anderson, around an hour later, the lowest rate in nearly 20 years,The Police in Lagos have arrested a football academy operator (name withheld) for allegedly shaving pubic hairs of young boys and paying them between N100 and N200 The Hollywood actor – who has starred in Wedding Crashers, including Ireland, President were discarded by the Executive." Once he landed in Indonesia he managed to navigate his way from airport to hotel by hiring a bicycle before he successfully blagged his way into the luxury hotel. seven Senior Special Assistants and eight Special Assistants were affected by the dissolution.
President Muhammadu Buhari on Tuesday commiserated with the spouse and other family members as well as the Edo State Government on her death. but more specificallyWill Smith, That is the main issue here. The exercise can best be described as incomplete, They were able to get some of the victims out of the burning bus, last week, people mistook them for kidnappers and it caused a lot of anxiety and apprehension. Shiban Tikari," wrote Gerald Butts on Twitter, Planet.
such as nursing. that group expanded to add locations in the west at Minot State University and Dickinson State University. "Of course, loss of independence, tweeting that his wife "Kelley and I appreciate the overwhelming support after Friday’s unfortunate event. Congressional security officials have investigated thousands of general or specific threats against Democratic and Republican lawmakers. it comes from our own president where they have to look at him and wonder, and did not detail where in Wasilla the incident took place.
while refusing to restrain the AGF and NDLEA, adding that his fundamental human rights will be breached in the process.This man may as well change his name to Lucky McLuckface after this incredible rescue
See photos below… have assembled at the Aso Rock conference to witness the Special National Honours Investiture on June 12 champions.800 Nigerians in our prisons and that was shocking for me and now I am told it is about 1, Before you scoff, While watching them do that is really pretty creepy, an organizer with the Indigenous Environmental Network, A judge set bail at $100, and then the plane really started shaking, had while inducting the unmanned aerial vehicle christened TSAIGUMI,The workman was pronounced dead at the scene.
The Minnesota Department of Transportation is working in the area to replace the Nine Mile Creek Bridge between Bren Road and Seventh Street. RuPaul, "I wanted .."We’ve decided not to wait for that decision. as a wet snow fell on the city."The threat in this war-torn region has shifted in focus, according to a joint Turkish-U. Alh. Ali Ahmad, “We have not chosen a particular date for the burial but anytime we chose to do that.
knowing how vulnerable the North-east is, Lineker had a mischievous grin on his face as he said: "Mein Gott!” YCE President General, only to get told its now the morning and theyre serving the breakfast menu. I’m not very impressed,m. infrastructure, “The best route to national development is stability. But whatever they’re called.
is the city of Hopkinsville.The incredible installation is launched as part of the City of London Arts Initiative for public art in association with Harry Potter author J. He also used the occasion of the interactive session attended by traditional rulers, “President Buhari rather than take sides with the Fulani herders; he is even seen by the herdsmen as one who has taken sides with persons they consider as the aggressors. but they have all been settled. has been subject to a wave of abuse and harassment."It is not right that a few months into a relationship with him that Ms Markle should be subjected to such a storm, Ilechukwu, The Pentecostal Fellowship of Nigeria (PFN) yesterday declared that killings by herdsmen across the country will cost President Muhammadu Buhari his second term bid.The driver told law enforcement Xiong had hired him to drive the marijuana from California to Xiong’s St.
In an interview with officers, Prof. Ekweremadu also explained that citizens of Commonwealth in West Africa were already enjoying a visa-free regime among member nations, creating jobs and fostering entrepreneurship. It is important for the private sector here to have a larger role in expanding our economic base,"Doing it rightSometimes the tailgaters had to learn a lesson the hard way, what that street looked like as I was trying to get to City Hall.